Cerclage progesterone pessary containing extended release, sustained and continuous, useful for Prevention of Preterm Birth

摘要

The Invention relates to a cerclage pessary containing progesterone pessary homogeneously distributed in the body, providing a prolonged release, sustained and continuous for a period of at least 6 months.The pessary is formed by elastomeric dimethylsiloxane with RTV (room Temperature Vulcanization mechanism), the amount of progesterone is between 20% to 30% w / W, The Weight of the pessary and proportions of the Polymers that form the Matrix, is between 6 to 14: 1: 1. The pessary cerclage of the invention is useful for the Prevention of Preterm Birth.Progesterone diffuses through the polymer continuously, without altering the shape and Integrity of the pessary, given that the elastomer to form the polymer Matrix is not biodegradable, ensuring that the shape of the pessary is kept intact until the end of Treatment