Novel anti-aging peptides and cosmetic and / or pharmaceutical composition containing them

摘要

Peptide compound of the following general formula (I): R1- (AA) n- X1-Ser-Thr-Pro-X2 - (AA) p-R2 in which X1 represents a threonine, a serine or is equal to zero , X2 represents an isoleucine, a leucine, a valine, an alanine, a glycine or is equal to zero, AA represents any amino acid except proline, or one of its derivatives, and n and p are integers between 0 and 4, R1 represents the primary amine function of the N-terminal amino acid, free or substituted by a protecting group which can be selected from an acetyl group, a benzoyl group, a tosyl group or a benzyloxycarbonyl group, R2 represents the hydroxyl group of the carboxyl function of the amino acid C terminal, substituted by a protecting group which can be selected from a C1 to C20 alkyl chain, or an NH2, NHY or NYY group in which Y represents a C1 to C4 alkyl chain, said sequence of general formula (I being constituted ) by 3 to 13 amino acid residues , characterized in that it corresponds to one of the following formulas: (SEQ ID No. 1) Tyr-Val-Ser-Thr-Pro-Tyr-Asn-NH2 (SEQ ID No. 2) Val-Ser-Thr - Pro-Glu-NH2 (SEQ ID # 3) Ser-Thr-Pro-NH2 (SEQ ID # 4) Leu-His-Ser-Thr-Pro-NH2 (SEQ ID # 5) Arg-His - Ser-Thr-Pro-Glu-NH2 (SEQ ID No. 6) His-Ser-Thr-Pro-Glu-NH2, and allows to restore the circadian rhythm and resynchronize the biological clock of skin cells.