RESOLUTION AND PURIFICATION OF TRANS-(-)-DELTA-9-TETRAHYDROCANNABINOL AND TRANS-(+)-DELTA-9-TETRAHYDROCANNABINOL BY CHIRAL CHROMATOGRAPHY

摘要

Methods for making trans-(-)-.DELTA.9-tetrahydrocannabinoI and trans-(+)-.DELTA.9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(-)-.DELTA.9-tetrahydrocannabinoI composition is prepared by allowing acomposition comprising (~)-.DELTA.9-tetrahydrocannabinol to separate on achiral stationary phase to provide a trans-(-)-.DELTA.9-tetrahydrocannabinoIcomposition comprising at least about 99% by weight of trans-(-)-.DELTA.9-tetrahydrocannabinol based on the total amount of trans-(-)-.DELTA.9-tetrahydrocannabinol and trans-(+)-.DELTA.9-tetrahydrocannabinol. Theinvention also relates to methods for treating or preventing a condition suchas pain comprising administering to a patient in need thereof an effectiveamount of a trans-(-)-.DELTA.9-tetrahydrocannabinoI having a purity of atleast about 98% based on the total weight of cannabinoids.