FAM26F polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics

摘要

#$%^&*AU2014201027B220151119.pdf#####ABSTRACT This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.1728,8864.4+ + -4 + + +N -4 '~ + + C C CD c (D + + c) C - - .9C?99 6 "(N N (Nj ce (NJ I~ IN IN pN Cfl~c)Y) CY~ I CY 0- E -3 a) M CUB () ) a) a -c- , Ed E E E 0 ~ 0 E __ 0 2 n uj ) ~ S~ ~~C -~ - -L U~~ ) a ) cu 0 S_-a 1/73