BANK VOLE PRION PROTEIN AS A BROAD-SPECTRUM SUBSTRATE FOR RT-QUIC-BASED DETECTION AND DISCRIMINATION OF PRION STRAINS

摘要

In some embodiments, a method is disclosed for detecting a transmissible spongiform encephalopathy in a subject. In some embodiments, the method includes performing a prion protein amyloid seeding assay on a biological sample from the subject to detect PrP^D. In additional embodiments, a method is disclosed for discriminating whether a bovine is affected by classical or atypical L-type or H-type bovine spongiform encephalopathy, an ovine is affected by classical or atypical Nor98 scrapie, or a human is affected by sporadic or variant Creutzfeldt- Jakob disease.