-1 IL1 RAP Anti Human Interleukin-1 Receptor Accessory Protein IL1 RAP Antibodies and Uses thereof

摘要

The present invention provides an antibody or antigen-binding fragment thereof having binding specificity for a human interleukin-1 receptor accessory protein (IL1RAP), wherein the antibody or antigen-binding fragment comprises an antibody 'CAN04' Lt; RTI ID = 0.0 IL1RAP / RTI The invention further provides the use of such antibodies or antigen-binding fragments in the treatment and / or diagnosis of IL-1 associated diseases and disorders, wherein said IL-1 associated diseases and disorders are cancer, such as acute myelogenous leukemia and melanoma .