/ Inhibitors of Akt/PKB with anti-tumor activity

摘要

The present invention relates to materials and methods that inhibit the Akt / PKB pathway. In one embodiment, the compounds of the present invention inhibit the kinase activity and / or phosphorylation level of the Akt protein. The invention also relates to a method of inhibiting or killing such cells, comprising contacting an effective amount of a compound of formula I with cancer cells or other cells whose expression of Akt protein is elevated or constitutively active. The invention also relates to a method of treating cancer or a tumor in a human or animal, comprising administering to the human or animal an effective amount of a compound of formula (I).