IL-12 Composition for treating hepatic cancer comprising mesenchymal stem cell transfected with IL-12 expressing vector and the treatment methods using the same

摘要

The present invention relates to a composition for treating liver cancer and a method for treating liver cancer in a mammal, which comprises mesenchymal stem cells transduced with an adenovirus vector expressing IL-12, wherein the expression of IL-12 is increased from the mesenchymal stem cells The present invention provides a composition for treating liver cancer comprising mesenchymal stem cells transfected with an adenovirus vector expressing IL-12 in combination with radiation therapy to enhance anti-cancer immunological activity in liver cancer cells. Induces apoptotic effects, so it has less side effects than conventional chemotherapy, and can further enhance the efficacy of radiotherapy.