MODEL antibody dependent cellular cytotoxicity in a living organism

摘要

1. A transgenic animal, non-human, humanized locus containing the low-affinity receptor FcgR.2. The animal, non-human, according to claim. 1, wherein the low-affinity receptor endogenous genes FcgR completely replaced by low-affinity receptor genes FcgR cheloveka.3. The animal, non-human, according to claim. 1 or 2, wherein the animal, non-human, is mlekopitayuschee.4. The animal, non-human, according to claim. 3, wherein the animal, non-human, is gryzuna.5. The animal, non-human, at para. 4, where the animal, non-human, is mysh.6. A descendant of the animal, a non-human, in percentage points 1-5 resulting from interbreeding with animals of the same or another genotipa.7. Cell line or primary culture cells derived from an animal, non-human, in percentage points 1-5 or a descendant of claim. 6.8. Tissue or organ explant or a culture derived from animals, non-human, in percentage points 1-5 or on a descendant of claim. 6.9. The use of an animal, non-human, in any one of 1-5, a descendant of claim. 6, a cell line or primary cell culture according to claim. 7 or explant tissue or organ according to claim. 8 to determine the effectiveness antitel.10. The method for determining the effectiveness of antibodies include the grafting of the tumor cell or animal tumors that do not belong to the person of any one of 1-5, or a descendant of n. 6 and the introduction of this antibody to the animal that do not belong to the person or potomku.11. A method for evaluating the potential security risk of therapeutic antibodies comprising administering to the animal an antibody other than an hour