SIX-BENZYLPHENYL-2-SULFURTETRAHYDROPYRAN-3,4,5-TRIOL DERIVATIVES AS INHIBITORS OF SODIUM-GLUCOSE COTRANSPORTERS 1 AND 2 FOR USE IN DIABETIC PATIENTS

摘要

PROBLEM TO BE SOLVED: To provide methods of improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, and to provide compounds and pharmaceutical compositions useful in the method.SOLUTION: A compound for use in improving the cardiovascular or metabolic health of a diabetic or pre-diabetic patient is used at a dose of 300 mg/day or less (e.g., 250 mg/day, 200 mg/day, 150 mg/day, 100 mg/day or 50 mg/day or less), being represented by the following formula.(where R represents a hydrogen, an alkyl, an aryl, or a heterocycle or the like.)SELECTED DRAWING: Figure 1