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Toilet that detects fluorescent drug markers and methods of use thereof

机译:检测荧光药物标记的马桶及其使用方法

摘要

The present disclosure describes a method of detecting a drug marker in urine a urine sample using a toilet. The drug markers are fluorophores each of which emits a unique fluorescence spectra. Accordingly, the method does not detect the drug but rather, the drug marker. The drug marker may include quantum dots which may be functionalized by connecting the quantum dot to a biomolecule. The biomolecule may be cleavable by a peptidase, a protease, or a nuclease to release the drug. Alternatively, the composition may include a liposome carrier. A user who has consumed the drug composition urinates into the toilet and a urine sample is captured. The toilet includes a mechanism for fluid handling which diverts urine into a fluorescence spectrometer. The fluorescence spectrometer screens the urine for drug markers based on their unique fluorescent spectra.
机译:本公开描述了一种使用厕所检测尿液和尿液样本中的药物标记物的方法。药物标记是荧光团,每个荧光团发出独特的荧光光谱。因此,该方法不是检测药物而是检测药物标记。药物标记物可以包括可以通过将量子点连接到生物分子而被官能化的量子点。该生物分子可以被肽酶,蛋白酶或核酸酶切割以释放药物。或者,所述组合物可包含脂质体载体。消耗了药物组合物的使用者将小便排入厕所并捕获尿液样本。马桶包括用于流体处理的机构,该机构将尿液转移到荧光光谱仪中。荧光光谱仪根据其独特的荧光光谱筛选尿液中的药物标记。

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