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Broadly protective Shigella vaccine based on type III secretion apparatus proteins

机译：基于III型分泌设备蛋白的广泛保护性志贺氏菌疫苗

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摘要

Broad-based, cross-protective, O-serotype independent vaccines against Shigella and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed. 展开▼

机译：提供了针对志贺氏菌和相关病原生物的基础广泛，具有交叉保护作用的O型血清型独立疫苗。疫苗包含一种或多种III型分泌（TTS）装置针蛋白IpaD和IpaB，和/或IpaB同源伴侣蛋白IpgC。也包括IpaD和IpaB和/或IpgC的嵌合蛋白。 展开▼

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公开/公告号US9492523B2

专利类型

公开/公告日2016-11-15

原文格式PDF

申请/专利权人 THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY;
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申请/专利号US201213709689

发明设计人 WENDY L. PICKING;WILLIAM D. PICKING;
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申请日2012-12-10

分类号A61K39/395;A61K39/112;C07K14/25;A61K39;

国家 US

入库时间 2022-08-21 13:43:15

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