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Method for assessing repetitive head injuries with two-dimensional magnetic resonance spectroscopy

机译:二维磁共振波谱法评估重复性颅脑损伤的方法

摘要

A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.
机译:提供了一种使用磁共振成像(MRI)系统产生指示受试者中重复性头部损伤的生物标记物的方法。使用MRI系统从对象获取二维光谱数据。从二维光谱数据产生二维光谱。二维光谱包含由第一光谱尺寸和第二光谱尺寸指示的光谱信息。这样的二维频谱可以包括对角峰和非对角线或交叉峰。在这种情况下,每个交叉峰可以指示,例如,它在对角线上连接的两个质子之间的标量耦合。但是,根据所用方法的类型,也可能存在不同类型的耦合。使用二维光谱,识别指示受试者中重复性颅脑损伤的生物标志物,并且可以将其用于产生指示神经功能障碍的状态或消退的报告。

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