spiro- 1,3 oxoxins and spiro- 1,4 oxazepines as inhibitors of bace1 and / or bace2

摘要

patent summary: "spiro- [1,3] oxazine and spiro [1,4] oxazepine as inhibitors of bace1 and / or bace2". The present invention relates to spiro- [1,3] oxazins and spiro- [1,4] oxazepines of formula I having bace1 and / or bace2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and / or prophylactic treatment of, for example, Alzheimer's disease and type 2 diabetes.