Guanilhidrazu00f4nicos derivatives as potentiators of antibiotic action by modulating action of efflux pumps

摘要

Guanilhidrazu00f4nicos derivatives as potentiators of antibiotic action by modulating action of efflux pumps.The present invention provides the use of guanilhidrazu00f4nicos derivatives as potentiators of antibiotic action by modulating action of efflux pumps, these are agents modifying antibiotic activity in front of strains of antibiotic resistant bacteria by conventional. You 're the inhibition of the efflux system.The compounds guanilhidrazu00f4nicos (1, 19) were synthesized through the procedures using traditional methodology involving the condensation of aminoguanidine under reflux with aromatic aldehydes.These compounds present in concentration subinibitoria, modulating activity with conventional antibiotics, inhibiting microbial resistance in front of the action of these antibiotics, and so, as an adjunct to antibiotics, which may be used in therapy for human use. Or veterinary treatment of infections by micro-organisms.