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methods for tumor metastasis prevention, cancer treatment and prognosis, and identification of agents that are putative metastasis inhibitors

机译:预防肿瘤转移,治疗和预后的方法以及鉴定可能的转移抑制剂的方法

摘要

A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
机译:提供了一种以肿瘤不是神经胶质瘤为前提的预防肿瘤转移的方法。该方法包括向有此需要的受试者施用治疗有效量的突触结合蛋白2(SYNJ2)的抑制剂,从而防止肿瘤转移。另外,提供了一种治疗癌症的方法。该方法包括向有此需要的受试者施用治疗有效量的突触核蛋白2抑制剂(SYNJ2)和与癌症的发生或发展相关的细胞表面受体的抑制剂,从而治疗癌症。

著录项

  • 公开/公告号BR112015002626A2

    专利类型

  • 公开/公告日2017-09-26

    原文格式PDF

  • 申请/专利权人 YEDA RESEARCH AND DEVELOPMENT CO. LTD.;

    申请/专利号BR20151102626

  • 发明设计人 NIR BEN-CHETRIT;YOSEF YARDEN;

    申请日2013-11-28

  • 分类号A61K39/395;A61K31/353;A61K31/7048;A61K45/06;A61P35;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:18

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