ethinyl derivatives as modulators of mglur5 receptor activity

摘要

Patent Summary: "Ethinyl derivatives as modulators of mglur5 receptor activity". The present invention relates to the ethinyl derivatives of formula (I) or a pharmaceutically acceptable acid addition salt, a racemic mixture, or their corresponding enantiomer and / or optical isomer and / or stereoisomer thereof. It has now surprisingly been found that the compounds of formula (I) are metabotropic glutamate receptor agonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, fragile x syndrome, autistic spectrum disorders, parkinson's disease. , and gastroesophageal reflux disease (gerd).