USE OF VITAMIN E TOCOTRIENOLS FOR THE INHIBITION OF INTRACELLULARLY OBLIGATE PATHOGEN CHLAMYDIA

摘要

THIS INVENTION REVEALS THE BENEFICIAL USE OF VITAMIN E TOCOTRIENOLS FOR INHIBITION OF CHLARNYDIAL INFECTIONS. CHLAINYDIAL INFECTION LEVELS IN MOUSE MACROPHAGES TREATED WITH TOCOTRIENOL WERE DECREASED 50, WITH CONCOMITANT ABERRANT PATHOGEN DEVELOPMENT. THE NUMBER OF LARGE AND SMALL INCLUSIONS IN TOCOTRIENOL-VERSUS-CONTROL CELLS WAS DECREASED 3- FOLD AND 2-FOLD, RESPECTIVELY. WHEN TREATED WITH DELTA TOCOTRIENOL, CHLAMYDIA IN HUMAN LYMPHOCYTES WAS INHIBITED BY AT LEAST 2.6-FOLD IN 1.5 DAYS. DIETARY DELTA TOCOTRIENOL INHIBITED CHLAMYDIA INFECTION AND PERSISTENCE IN HYPERCHOLESTEROLERNIC PATIENTS WITH A CORRESPONDING DROP IN LDL. THESE STUDIES DEMONSTRATE THAT TOCOTRIENOL LOWERS CHOLESTEROL, THUS PREVENTING OR DIMINISHING THE CHOLESTEROL HIJACKING BY CHLAMYDIA OBLIGATORY FOR ITS INFECTIVITY AND REPLICATION. THEREFORE, HYPOLIPIDERNIC AGENTS USED TO TREAT CARDIOVASCULAR DISEASES, METABOLIC SYNDROME, AND DIABETES ARE USED AS MONOTHERAPICS, OR IN COMBINATION WITH TOCOTRIENOL TO TREAT CHLAMYDIA.