3-Oxo-2,3-dihydro-1H-indazol-4-carboxamide derivatives as PARP-1 inhibitors

摘要

A compound of formula (I): ** Formula ** wherein R1 is an optionally substituted group selected from C3-C7 cycloalkyl, heterocyclyl, aryl and heteroaryl; R2 is hydrogen, COR4 or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl and heteroaryl; R3 is hydrogen, halogen, cyano, nitro, NHCOR4, COR4, NR5R6, NR5COR4, OR7, SR7, SOR10, SO2R10, NHSOR10, NHSO2R10, or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, R8R9NC1-C6 alkyl and R8O-C1-C6 alkyl; R4 is hydrogen, NR5R7, OR7, SR7, or an optionally substituted group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, R8R9N-C1-C6 alkyl and R8O-C1-C6 alkyl; R5 and R6 are independently hydrogen, or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, R8R9N-C1-C6 alkyl and R8O-C1-C6 alkyl, or R5 and R6 taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl group; R7 is hydrogen, COR5, SOR10, SO2R10 or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, R8R9N-C1-C6 alkyl , R8O-C1-C6 alkyl, heterocyclyl-C1-C6 alkyl, aryl-C1-C6 alkyl and heteroaryl-C1-C6 alkyl, where R5 is as defined above; R8 and R9 are independently hydrogen, COR4 or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl and heteroaryl, or R8 and R9, taken together with the nitrogen to which they are attached, they form an optionally substituted heterocyclyl group, where R 4 is as defined above; R10 is hydrogen, NR5R6, OR7 or an optionally substituted group selected from linear or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, heterocyclyl, aryl, heteroaryl, R8R9NC1-C6 alkyl, R8O alkyl -C1-C6, where R5, R6, R7, R8 and R9 are as defined above; or a pharmaceutically acceptable salt thereof.