SYNTHETIC PHOSPHODIESTER OLIGONUCLEOTIDES AND THERAPEUTICAL USES THEREOF

摘要

A composition of phosphodiester oligonucleotides of various defined sizes hasbeen created that mimics the effectsof defibrotide. The composition essentially consists of mixtures of syntheticphosphodiester oligonucleotides comprising Nmersranging from 40 mers to 65 mers. The phosphodiester oligonucleotides arepreferably heteropolymers composed of either A, G, C,and T at each position but may also be homopolymers, i.e. the same base may bepresent at each position in the oligonucleotide.These mixtures are effective in the treatment of cancer and other diseases.