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ERGIC3 Pharmaceutical composition comprising ERGIC3 inhibitor for preventing and treating cancer

机译:ERGIC3用于预防和治疗癌症的包含ERGIC3抑制剂的药物组合物

摘要

The present invention relates to a composition for preventing or treating cancer, comprising an ERGIC3 inhibitor, a gene therapy agent, a drug carrier, and an aerosol formulation thereof. The ERGIC3 inhibitor of the present invention induces ER stress in cancer cells and thus induces the autophagy of the cancer cells, thereby being able to inhibit the proliferation of the cancer cells and promote death of the cancer cells. In particular, normal cells do not induce such autophagy, thereby being able to be usefully used as a cancer cell-specific therapeutic agent without toxicity.
机译:本发明涉及用于预防或治疗癌症的组合物,其包含ERGIC3抑制剂,基因治疗剂,药物载体及其气雾剂。本发明的ERGIC3抑制剂在癌细胞中诱导ER应激,从而诱导癌细胞自噬,从而能够抑制癌细胞的增殖并促进癌细胞的死亡。特别地,正常细胞不会诱导这种自噬,因此能够有效地用作癌细胞特异性治疗剂而没有毒性。

著录项

  • 公开/公告号KR20170021084A

    专利类型

  • 公开/公告日2017-02-27

    原文格式PDF

  • 申请/专利权人 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;

    申请/专利号KR20150115457

  • 发明设计人 HONG SEONG HO;CHO MYUNG HAING;

    申请日2015-08-17

  • 分类号A61K48/00;A61K31/713;A61K9/00;A61K9/12;

  • 国家 KR

  • 入库时间 2022-08-21 13:28:04

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