-HER2 IMMUNOCONJUGATES COMPRISING ANTI-HER2 ANTIBODIES AND PYRROLOBENZODIAZEPINES

摘要

The present invention provides an immunoconjugate comprising an anti-HER2 antibody and a method of using the same. An immunoconjugate is provided, which comprises an antibody and a cytotoxic agent, wherein the cytotoxic agent is a centrally-linked pyrrolobenzodiazepine. Said immunoconjugate having the formula Ab- (L-D) p, wherein: a) Ab is an antibody according to any one of claims 1 to 16; b) L is a linker; c) D is a center-connected pyrrolobenzodiazepine; And d) p ranges from 1 to 8.