-VEGF STABLE PROTEIN SOLUTION FORMULATION CONTAINING HIGH CONCENTRATION OF AN ANTI-VEGF ANTIBODY

摘要

The present invention provides anti-VEGF antibodies formulated as highly concentrated aqueous pharmaceutical compositions suitable for injection, preferably intravitreal injection. Aqueous pharmaceutical compositions are useful for delivering high concentrations of antibody-active ingredients to patients without high levels of antibody aggregation and without high levels of visibly invisible particulate matter. The aqueous compositions of the present invention comprise an antibody having a concentration of at least 50 mg / ml. The aqueous pharmaceutical compositions of the present invention include sugars, buffers and surfactants.