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Understanding physical and chemical stability of proteins in solution: Relevance to therapeutic protein and monoclonal antibody formulations

机译：了解溶液中蛋白质的物理和化学稳定性：与治疗性蛋白质和单克隆抗体制剂的相关性

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作者
Thirumangalathu, Renuka;
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作者单位

University of Colorado Health Sciences Center;

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授予单位 University of Colorado Health Sciences Center;
学科
学位 Ph.D.
年度 2007
页码 143 p.
总页数 143
原文格式 PDF
正文语种 eng
中图分类
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专利

1. Ultrasonic rheology of a monoclonal antibody (IgG2) solution: implications for physical stability of proteins in high concentration formulations. [J] . Saluja A, Badkar AV, Zeng DL, Journal of pharmaceutical sciences. . 2007,第12期

机译：单克隆抗体（IgG2）溶液的超声流变学：对高浓度制剂中蛋白质物理稳定性的影响。
2. A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody. [J] . Le Brun V, Friess W, Bassarab S, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2010,第1期

机译：自我相互作用色谱的关键评估作为评估蛋白质制剂开发中蛋白质相互作用的预测工具：治疗性单克隆抗体的案例研究。
3. Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations [J] . Chiu Josephine, Valente Kristin N., Levy Nicholas E., Biotechnology and Bioengineering . 2017,第5期

机译：敲除难以去除的CHO宿主细胞蛋白，脂蛋白脂肪酶，用于改善单克隆抗体制剂中的聚山梨醇酯稳定性
4. Selection of Monoclonal Antibodies Targeting Therapeutic Membrane Proteins Through a Cell-Based Phage Display Panning System [C] . Yu Jung Kim, Bin Yoo, Yoonji Kim, Protein Engineering Summit. . 2018

机译：通过基于细胞的噬菌体展示平移系统靶向治疗膜蛋白的单克隆抗体的选择
5. Physical stability of proteins in solution: Relevance to therapeutic formulations and protein deposition diseases [D] . Krishnan, Sampathkumar 2002

机译：蛋白质在溶液中的物理稳定性：与治疗配方和蛋白质沉积疾病的相关性
6. Knockout of a difficult-to-remove CHO host cell protein lipoprotein lipase for improved polysorbate stability in monoclonal antibody formulations [O] . Josephine Chiu, Kristin N. Valente, Nicholas E. Levy, -1

机译：敲除难去除的CHO宿主细胞蛋白脂蛋白脂肪酶以改善单克隆抗体制剂中的聚山梨酯稳定性
7. Identification and characterization of a residual host cell protein hexosaminidase B associated with N ‐glycan degradation during the stability study of a therapeutic recombinant monoclonal antibody product [O] . Xuanwen Li, Yan An, Jing Liao, 2021

机译：治疗重组单克隆抗体产物的稳定性研究期间与N-Glycan降解相关的残留宿主细胞蛋白己糖胺酶B的鉴定及表征

Understanding physical and chemical stability of proteins in solution: Relevance to therapeutic protein and monoclonal antibody formulations

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