HCC NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST HEPATOCELLULAR CARCINOMA HCC AND OTHER CANCERS

摘要

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to immunotherapy of cancer. The present invention also relates to a pharmaceutical composition for the treatment of a patient suffering from a disease or condition selected from the group consisting of, for example, in combination with other tumor-associated peptides capable of acting as an active pharmaceutical ingredient of a vaccine composition, Tumor-associated T cell peptide epitope. Peptides bound to molecules of the main histochemical complex (MHC) or such peptides may be targets of antibodies, soluble T cell receptors and other binding molecules. In particular, the invention relates to a vaccine composition which is derived from HLA class I and HLA class II molecules of human tumor cells which can be used in vaccine compositions needed to elicit antitumor immune responses or as targets for the development of pharmaceutical / immunologically active compounds and cells To some novel peptide sequences and variants thereof.