HCC NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST HEPATOCELLULAR CARCINOMA HCC AND OTHER CANCERS

摘要

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapy methods. In particular, the present invention relates to immunotherapy of cancer. The present invention is also intended to promote an anti-tumor immune response or to promote T-cell ex vivo to a patient, either alone or in combination with other tumor-associated peptides that may serve as an active pharmaceutical component of a vaccine composition, for example. Tumor-associated T cell peptide epitopes. Peptides bound to molecules of the main histological complex (MHC) or such peptides may be targets of antibodies, soluble T cell receptors and other binding molecules. In particular, the present invention is derived from HLA class I and HLA class II molecules of human tumor cells that can be used as a target for the development of pharmaceutical/immunologically active compounds and cells in vaccine compositions necessary to elicit an anti-tumor immune response. It relates to several novel peptide sequences and variants thereof.