- P-TAU TRIAZOLOPYRIDINES AND TRIAZOLOPYRIMIDINES THAT LOWER STRESS-INDUCED P-TAU

摘要

In certain embodiments, a compound that is effective at lowering p-tau and / or preventing or reducing the elevation of p-tau in response to stress (e.g., elevated cortisol levels), such as a triazolopyrimidine (S) and / or triazolopyridine (s)). The five compounds are useful for the treatment or prevention of pathologies characterized by abnormal amyloid plaques and / or entanglement formation and / or deposition.