TREATMENT OF DISEASES ASSOCIATED WITH METHIONINE SULFOXIDE REDUCTASE A (MSRA), BY MSRA NATURAL ANTISENSE TRANSCRIPT INHIBITION

摘要

FIELD: biotechnology.;SUBSTANCE: oligonucleotides are described that modulate methionine sulfoxide reductase A (MSRA) expression, in particular, by targeting the interaction with the natural antisense methionine sulfoxide reductase A (MSRA) polynucleotides. This invention also relates to application of the said oligonucleotides for treatment of diseases and disorders associated with methionine sulfoxide reductase A (MSRA) expression.;EFFECT: invention expands the arsenal of tools for treatment of diseases and disorders associated with methionine sulfoxide reductase A (MSRA) expression.;28 cl, 2 dwg, 2 ex, 1 tbl