RECOMBINANT STAIN OF VACΔ6 VACCINIA VIRUS WITH BROKEN GENES OF VIRALENCE C3L, N1L, J2R, A35R, A56R, B8R FOR THE PRODUCTION OF LIVE CULTURAL ATTENUATED VACCINE AGAINST NATURAL SMALLPOX AND OTHER ORTHOPOXVIRAL HUMAN INFECTIONS

摘要

FIELD: biotechnology.;SUBSTANCE: recombinant strain of VACΔ6 vaccinia virus with broken genes C3L, N1L, J2R, A35R, A56R, B8R on the basis of cloned vaccinia virus (L-IVP strain). The proposed strain is deposited in State Collection of causative agents of viral infections, rickettsiosis of the SBSI of the SSC VB Vector with registration No. V-696 and is designed to produce a bladeless, attenuated live culture vaccine against the natural smallpox and other orthopoxviruses with enhanced immunogenic and protective activity.;EFFECT: proposed recombinant strain can be used in medicine to produce a vaccine against natural smallpox and other human orthopoxviral infections.;7 dwg, 2 tbl, 13 ex