首页> 外国专利> IDENTIFICATION OF NOVEL DISEASE STATES USING VISCOELASTIC ANALYSIS IN THE PRESENCE OF A THROMBOLYTIC AGENT

IDENTIFICATION OF NOVEL DISEASE STATES USING VISCOELASTIC ANALYSIS IN THE PRESENCE OF A THROMBOLYTIC AGENT

机译:在存在溶栓剂的情况下使用粘弹性分析识别新的疾病状态

摘要

In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent.
机译:在一些实施方案中,本发明提供了用于检测患者中异常的纤维蛋白溶解状况的方法。该方法包括在已知量的血栓溶解剂的存在下对来自患者的血液样品进行粘弹性分析,以获得患者的凝血特性值;将患者的凝结特征值与健康个体的凝结特征值进行比较,该健康个体的凝结特征值是通过在已知量的存在的情况下对来自健康个体的血液样本进行粘弹性分析而获得的。溶栓剂,其中患者的凝结特征值与健康个体的凝结特征值相比的差异将该专利确定为具有异常的纤维蛋白溶解。在一些实施方案中,本发明还提供了一种适于使用粘弹性分析来检测血液样品中异常纤维蛋白溶解状况的容器,该容器包括内部,该内部具有包含血栓溶解剂的涂层。

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