TREATMENT OF SODIUM CHANNEL, VOLTAGE-DEPENDENT, α SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SCNA

摘要

PROBLEM TO BE SOLVED: To provide antisense oligonucleotides that modulate the expression and/or function of sodium channel, voltage-dependent, α subunit (SCNA), in particular, by targeting natural antisense polynucleotides of sodium channel, voltage-dependent, α subunit.SOLUTION: The present invention provides an antisense oligonucleotide modulated by targeting a natural antisense polynucleotide of sodium channel, voltage-dependent, α subunit with respect to a biological system, the system being brought into contact with the antisense oligonucleotide, thereby, the function and/or expression of a SCN1A polynucleotide being upregulated, and the sequence of the antisense oligonucleotide being an oligonucleotide sequence selected from particular sequences.SELECTED DRAWING: Figure 1