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Electroporation system for controlling local delivery of therapeutic substances

机译:用于控制治疗物质局部递送的电穿孔系统

摘要

Embodiments of the present invention provide an electroporation system that includes at least two electrodes adjacent to each other configured to be inserted into a biological tissue for electroporation treatment; A pulse generator electrically connected to a probe, wherein one or more electrical pulse sequences are used to drive the electroporation probe and transmit current to the probe to cause unevenness in biological tissue near the probe electrode The pulse generator configured to induce an electric field. Treated tissue can be targeted by controlling parameters of probe configuration, carrier solution properties and electroporation pulse sequence to achieve predictable electroporation outcomes. This electroporation control method can also reduce the potentially harmful effects of electroporation procedures. [Selection] Figure 2b
机译:本发明的实施方式提供了一种电穿孔系统,该电穿孔系统包括至少两个彼此相邻的电极,所述至少两个电极被配置为插入到用于电穿孔处理的生物组织中。一种与探针电连接的脉冲发生器,其中一个或多个电脉冲序列用于驱动电穿孔探针并将电流传输到探针,以在探针电极附近的生物组织中引起不均匀性。脉冲发生器配置为感应电场。可通过控制探针配置,载体溶液性质和电穿孔脉冲序列的参数来靶向治疗的组织,以实现可预测的电穿孔结果。这种电穿孔控制方法还可以减少电穿孔程序的潜在有害影响。 [选择]图2b

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