Compounds and methods for assaying PEG metabolites and PEG degradation products

摘要

The present invention discloses compounds and methods for identifying and quantifying PEG metabolites or degradation products. Samples can be assayed for PEG metabolites or degradation products using liquid chromatography combined with mass spectrometry. The assay is optimized by derivatizing PEG metabolites or degradation products in the sample with pentaflurobenzoyl chloride and combined with liquid chromatography in negative chemical ionization mode. [Selection] Figure 3A