Refers to biespecu00edficas Antigen binding molecules comprising (a) at least one Rest capable of binding specifically to a target cell antigen, (b) at least one Rest capable of binding specifically to a member of the TNF Receptor Family coestimulador, and (c) AN FC domain. A First and a Second mpuesto subunit capable of stably Associate.And to methods for producing these molecules and Methods for using the same. Claim 2: The Molecule Binding to antigen biespecu00edfica of claim 1, in which the Member of the TNF Receptor family is selected from the group consisting of Ox40 and 4-1bb.
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机译：指biespec抗原结合分子，其包含（a）至少一种能够与靶细胞抗原特异性结合的Rest，（b）至少一种能够与TNF Receptor Family coestimulador成员特异性结合的Rest。 ）的FC域。能够稳定缔合的第一和第二mpuesto亚基，以及涉及产生这些分子的方法和使用该方法的方法。权利要求2：根据权利要求1所述的分子与抗原特异性抗体的结合，其中所述TNF受体家族的成员选自Ox40和4-1bb。
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