首页> 外国专利> The expression vector which comprises a polinucleotu00eddeo coding a glutamine synthetase modified, and a method for the preparation of a target protein that employs the same

The expression vector which comprises a polinucleotu00eddeo coding a glutamine synthetase modified, and a method for the preparation of a target protein that employs the same

机译:包含编码经修饰的谷氨酰胺合成酶的多核苷酸的表达载体,以及使用该载体的靶蛋白的制备方法

摘要

The present invention relates to a vector comprising a polynucleotide encoding a modified glutamine synthetase (GS), and a method for preparing a target protein employing the same. More particularly, the present invention relates to a modified GS having an increased sensitivity to a glutamine synthetase (GS) inhibitor, a polynucleotide encoding the modified GS, a vector comprising the polynucleotide, a transformant comprising the vector, and a method for preparing a target protein using the transformant.
机译:本发明涉及包含编码修饰的谷氨酰胺合成酶(GS)的多核苷酸的载体,以及使用该载体制备靶蛋白的方法。更具体地,本发明涉及对谷氨酰胺合成酶(GS)抑制剂具有增加的敏感性的修饰的GS,编码该修饰的GS的多核苷酸,包含该多核苷酸的载体,包含该载体的转化体以及制备靶的方法。蛋白使用转化子。

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