A vaccine composition comprising an immunogenic protein and combination adjuvants for use in promoting antigen-specific T-cell responses.

摘要

vaccine compositions for use in inducing enhanced antigen-specific t-cell mediated immune responses in a subject in need are disclosed. the composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least one pathogen antigen; (b) a saponin-based adjuvant selected from the group consisting of gpi-0100, quil a, qs-21; and (c) a toll-like receptor agonist (tlr) adjuvant selected from the group consisting of lipid monophosphoryl a (mpl) and cpg1826.