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OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1ALPHA EXPRESSION
OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1ALPHA EXPRESSION
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机译:用于调节HIF-1α表达的寡聚化合物
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摘要
Oligonucleotides directed against the hypoxia-inducible factor-1± (HIF-1±) gene are provided for modulating the expression of HIF-1±. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1±. Methods of using these compounds for modulation of HIF-1± expression and for the treatment of diseases associated with the hypoxia-inducible factor-1± are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
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