5 HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE

摘要

Provided in some embodiments are compounds herein. Also provided in some embodiments are methods for weight management inducing satiety and decreasing food intake and for preventing and treating obesity antipsychotic induced weight gain type 2 diabetes Prader Willi syndrome tobacco/nicotine dependence drug addiction alcohol addiction pathological gambling reward deficiency syndrome and sex addiction) obsessive compulsive spectrum disorders and impulse control disorders (including nail biting and onychophagia) sleep disorders (including insomnia fragmented sleep architecture and disturbances of slow wave sleep) urinary incontinence psychiatric disorders (including schizophrenia anorexia nervosa and bulimia nervosa) Alzheimer disease sexual dysfunction erectile dysfunction epilepsy movement disorders (including parkinsonism and antipsychotic induced movement disorder) hypertension dyslipidemia nonalcoholic fatty liver disease obesity related renal disease and sleep apnea. Also provided in some embodiments are compositions comprising a compound herein optionally in combination with a supplemental agent and methods for reducing the frequency of smoking tobacco in an individual attempting to reduce frequency of smoking tobacco; aiding in the cessation or lessening of use of a tobacco product in an individual attempting to cease or lessen use of a tobacco product; aiding in smoking cessation and preventing associated weight gain; controlling weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco; reducing weight gain associated with smoking cessation by an individual attempting to cease smoking tobacco; treating nicotine dependency addiction and/or withdrawal in an individual attempting to treat nicotine dependency addiction and/or withdrawal; or reducing the likelihood of relapse use of nicotine by an individual attempting to cease nicotine use comprising administering a compound herein optionally in combination with a supplemental agent.