首页>
外国专利>
COMPOSITIONS FOR TREATING FAMILIAL DYSAUTONOMIA BY ALTERING MRNA SPLICING
COMPOSITIONS FOR TREATING FAMILIAL DYSAUTONOMIA BY ALTERING MRNA SPLICING
展开▼
机译:改变MRNA剪接的治疗家族性肌张力障碍的组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin.
展开▼