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Methods for altering mRNA splicing and treating familial dysautonomia by administering benzyladenine
Methods for altering mRNA splicing and treating familial dysautonomia by administering benzyladenine
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机译:通过使用苄腺嘌呤改变mRNA剪接和治疗家族性自主神经的方法
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摘要
This invention relates to methods for altering the splicing of mRNA in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mRNA and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mRNA corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mRNA. In addition, this invention relates to treating individuals having a disorder associated with a misspliced mRNA, such as Familial Dysautonomia or Neurofibromatosis 1, by administering to such an individual a cytokinin such as kinetin.
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