AMORPHOUS SOLID DISPERSION FOR USE IN THE TREATMENT OF BRAIN CANCER

摘要

Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein. The compounds are N 4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine or (2-((4-((4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)amino)-4-methyl-4,5-dihydrooxazol-4-yl)methanol; they are for use in treating local or metastatic brain cancer wherein the brain cancer is ErbB2 positive.Optionally, other therapeutic agents are coadministered, most preferably trastuzumab or capecitabine.