Treatment of diseases related to nuclear respiratory factor 1 (NRF1) by inhibition of natural antisense transcript to NRF1

摘要

An oligonucleotide that targets a natural antisense transcript of nuclear respiratory factor 1 (NRF1) for use as a therapeutic compound, where the oligonucleotide increases the expression of nuclear respiratory factor 1 (NRF1), and where the natural antisense transcript has the sequence of nucleic acid as set forth in SEQ ID NO: 2, or a variant thereof that retains the function of the natural antisense transcript of SEQ ID NO: 2.