ANTI-CD19 ANTIBODIES AND USES IN ONCOLOGY

摘要

The invention relates to immunotherapeutic compositions and methods for thetreatment of B cell diseases and disorders in human subjects, such as, but notlimited to, B cell malignancies, using therapeutic antibodies that bind to thehuman CD 19 antigen and that preferably mediate human ADCC. The presentinvention relates to pharmaceutical compositions comprising human or humanizedanti-CD 19 antibodies of the IgGl or IgG3 human isotype. The present inventionrelates to pharmaceutical compositions comprising human or humanized anti-CD19 antibodies of the IgG2 or IgG4 human isotype that preferably mediate humanADCC. The present invention also relates to pharmaceutical compositionscomprising chimerized anti-CD19 antibodies of the IgGl, IgG2, IgG3, or IgG4isotype that mediate human ADCC. In preferred embodiments, the presentinvention relates to pharmaceutical compositions comprising monoclonal human,humanized, or chimeric anti-CD 19 antibodies.