SINGLE-DOMAIN ANTIBODY CAPABLE OF RECOGNIZING HUMAN SERUM ALBUMIN

摘要

Provided is a single-domain antibody capable of recognizing human serum albumin (HSA). By adopting a phage display technology, multiple strains of antibodies capable of specifically recognizing HSA are obtained by screening in a human single-domain antibody library. The antibodies contain only one variable region of an antibody heavy chain and are the smallest fully functional antigen-binding fragments, and have a smaller molecular weight and weaker immunogenicity than a single-chain antibody or antibody Fab fragment, and can function to extend the half-life of biological drugs when specifically bound to HSA. Single-domain antibodies with a high affinity are obtained by screening, and the antibodies can recognize specific human serum albumin and extend the half-life of biological drugs, facilitating the treatment of tumors.