VACCINE COMPOSITION CONTAINING ATTENUATED SALMONELLA MUTANT AS ACTIVE INGREDIENT FOR SIMULTANEOUSLY PREVENTING OR TREATING PORCINE PROLIFERATIVE ENTEROPATHY AND SALMONELLA

摘要

The present invention relates to a vaccine composition containing an attenuated Salmonella mutant as an active ingredient for simultaneously preventing or treating porcine proliferative enteropathy and Salmonella. The present invention was confirmed to induce humoral and cell-mediated immune responses to antigens in a mouse vaccinated with a mixture of the attenuated Salmonella mutant, when the attenuated salmonella was transformed using a vector developed to increase secretion of Lawsonia intracellularis-derived OptA, Optb, FliC or Hly antigens. Therefore, the mutant according to the present invention is expected to be useful as a vaccine for simultaneously preventing or treating porcine proliferative enteropathy and Salmonella, which is safe, economical, and safely inoculated.