The present invention relates to mutation of a plurality of genes contained in Salmonella typhimurium strains to prevent Salmonella infection in various animals. More specifically, the present invention relates to a method for preventing Salmonella infection in various animals by multiplymutatingssrA and ssrB regulatory genes, rpoS gene and hmpA gene , And to reduce or inhibit the persistent infectivity of Salmonella typhimurium in the host. Through the present invention, it is possible to contribute to the development of animal husbandry and pharmaceutical industry by providing a new vaccine which has less side effects than conventional vaccines and is safe and cost-competitive.
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