Composition for inducing direct conversion of somatic cell into hepatic stem cell hepatic cell or cholangiocyte

摘要

The present invention relates to: a composition for inducing direct conversion of somatic cells into at least one selected from a group consisting of induced hepatic stem cell (iHSC), hepatic cells and cholangiocytes; a method of direct conversion of the somatic cells into at least one selected from a group consisting of iHSC, hepatic cells and cholangiocytes comprising a step for introducing the composition into the somatic cells; and a pharmaceutical composition for preventing or treating liver diseases comprising at least one selected from a group consisting of hepatic cells differentiation-induced from direct conversion-induced iHSC, and the cholangiocytes.