Composition for inducing direct conversion of somatic cell into hepatic stem cell hepatic cell or cholangiocyte

摘要

The present invention relates to a composition for inducing cross-differentiation directly from somatic cells to at least one selected from the group consisting of induced hepatic stem cells (iHSC), hepatocytes, and bile duct cells, a somatic cell comprising the step of introducing the composition into somatic cells A method for directly crossing differentiation into one or more selected from the group consisting of liver stem cells, hepatocytes, and bile duct cells, and a method for directly crossing differentiation-induced liver stem cells, hepatocytes, and bile duct cells, Derived hepatic stem cells and hepatocyte cells derived from differentiated hepatic stem cells, and bile duct cells.