Single nucleotide polymorphism marker in gene for predicting risk of drug induced leukopenia and method for predicting risk of drug induced leukopenia using the same

摘要

The present invention relates to a composition for predicting drug-induced leukopenia risk including a single nucleotide polymorphism marker in APEX1 or GNB3 gene, and a method for predicting the risk of drug induced leukopenia. The single nucleotide polymorphism marker in the APEX1 or GNB3 gene according to the present invention has a high correlation with the risk of leukopenia induced by drugs, in particular, thiopurine-based drugs. Thus, leukemia, Crohn''s disease, ulcerative colitis , Or patients who are highly susceptible to leukopenia caused by thiopurine-based drug treatment such as organ transplantation can be effectively predicted or diagnosed early, thereby achieving optimal therapeutic effects by administering appropriate drugs to patients Patient-specific treatment can be performed efficiently. Furthermore, the single nucleotide polymorphic marker according to the present invention can be utilized for drug development studies for the treatment of drug induced leukopenia.