Pharmaceutical compositions for treatment or prevention of idiopathic pulmonary fibrosis

摘要

The present invention is beta-Rapa Village (β-lapachone) or dew trunnion (dunnione), or idiopathic pulmonary containing their pharmaceutically acceptable salts, its prodrug (prodrug), solvate or isomer thereof as an active ingredient of Rapa Village or administration of a dew Canyon - fibrosis pharmaceutically that the composition according to, bleomycin back (bleomycin) produced the mouse animal model with idiopathic pulmonary fibrosis using, beta for treatment or prevention of (idiopathic pulmonary fibrosis) confirming the effect result, a variety of inflammatory cell infiltration in the lung tissue using the bleomycin, the cells air quality were dense and fibrous degree of tissue loss due to the accumulation, bleomycin the azithromycin increased by IL-6, of the TGF-β1 and αSMA If the expression of the decrease was, combination treatment the dew Canyon after bleomycin administration, increased survival, but also confirm the significant increase of NAD ⁺ / NADH ratio As such, beta-Rapa Canyon Village, or dew may be useful in the treatment or prevention of idiopathic pulmonary fibrosis.;